For patching issues caused by Mar 2018 KB's on Server 2008 This is what have worked for us for now: Create a sccm package to deploy the following vbs script on all 2008 R2 servers collection Run it before the patches are applied (it will delete SlotPersistentInfo key if that exists under HKLM\System\CurrentControlSet\Enum\PCI\<deviceid>\<subdeviceid>\Device Parameters Let patches install Reboot The key will be recreated automatically after the reboot ************************** Script: Dim strPciFileVersion Dim WindirFilePath set WshShell = WScript.CreateObject("WScript.Shell") WindirFilePath = WshShell.ExpandEnvironmentStrings("%WinDir%") Dim fs Set fs = CreateObject("Scripting.FileSystemObject") strPciFileVersion = fs.getfileversion(WindirFilePath & "\\system32\\drivers\\pci.sys") Dim strAryFileVersion1 strAryFileVersion1 = Split(strPciFileVersion, ".") If (strAryFileVersion1(0) = 6...